top of page
Rechercher

Synthesis of NVS-BPTF-1 and evaluation of its biological activity

  • Photo du rédacteur: Groupe Gagnon
    Groupe Gagnon
  • 16 juin 2021
  • 1 min de lecture

BPTF (bromodomain and PHD finger containing transcription factor) is a multidomain protein that plays essential roles in transcriptional regulation, T-cell homeostasis and stem cell pluripotency. As part of the chromatin remodeling complex hNURF (nucleosome remodeling factor), BPTF epigenetic reader subunits are particularly important for BPTF cellular function. Here we report the synthesis of NVS-BPTF-1, a previously reported highly potent and selective BPTF-bromodomain inhibitor. Evaluation of the impact of the inhibition of BPTF-bromodomain using NVS-BPTF-1 on selected proteins involved in the antigen processing pathway revealed that exclusively targeting BPTF-bromodomain is insufficient to observe an increase of PSMB8, PSMB9, TAP1 and TAP2 proteins.


Léa Mélin, Cyrus Calosing, Olesya A. Kharenko, Henrik C. Hansen et Alexandre Gagnon





 
 
 

Comments


Logouqam quadrille.png

Alexandre Gagnon, Ph.D.

Professeur titulaire

Université du Québec à Montréal, Département de chimie

2101 Rue Jeanne-Mance, Montréal, Québec, Canada, H2X 2J6

Email: gagnon.alexandre@uqam.ca

Tel: 514.987.3000 ext 6856

  • LinkedIn Social Icône

Designed and created by Bianca Bueno and Alexandre Gagnon

© 2020 Alexandre Gagnon

bottom of page