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SYNTHESIS OF ARYL CYCLOPROPYL SULFIDES

  • Photo du rédacteur: Groupe Gagnon
    Groupe Gagnon
  • 27 mai 2019
  • 1 min de lecture

Dernière mise à jour : 5 juil. 2020

Synthesis of aryl cyclopropyl sulfides through copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acids






The copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid is reported. The procedure operates under simple conditions to afford the corresponding aryl cyclopropyl sulfides in moderate to excellent yields. The reaction tolerates substitution in ortho-, meta- and para-substitution as well as electron-donating and electron-withdrawing groups. The S-cyclopropylation of a thiophenol was also accomplished using potassium cyclopropyl trifluoroborate.


Emeline Benoit, Ahmed Fnaiche and Alexandre Gagnon






 
 
 

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Alexandre Gagnon, Ph.D.

Professeur titulaire

Université du Québec à Montréal, Département de chimie

2101 Rue Jeanne-Mance, Montréal, Québec, Canada, H2X 2J6

Email: gagnon.alexandre@uqam.ca

Tel: 514.987.3000 ext 6856

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