O-ARYLATION OF TYROSINE
Mis à jour : 21 août 2020
A general method for the O‐arylation of the side chain of tyrosine using triarylbismuth reagents is reported. The reaction is mediated by copper diacetate, operates at 50 °C under oxygen in dichloromethane in the presence of pyridine, shows excellent functional group compatibility and retains the integrity of the stereogenic center. The protocol was used to arylate the tyrosine residue in dipeptides and tripeptides.
Adrien Le Roch, Martin Hébert and Alexandre Gagnon