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  • Groupe Gagnon

HEAVY METAL ORCHESTRATION

Mis à jour : 5 juil. 2020





Many current methods to prepare 2-hydroxybiaryls require the prefunctionalization of phenol groups or show limited substrate scope. Now, use of a pentavalent sulfone-bridged bismacycle, formed in situ by telescoped boron-to-bismuth transmetallation and oxidation, allows the direct and regioselectiveortho-arylation of unprotected phenols.


Adrien Le Roch and Alexandre Gagnon.






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