HEAVY METAL ORCHESTRATION
Dernière mise à jour : 5 juil. 2020
Many current methods to prepare 2-hydroxybiaryls require the prefunctionalization of phenol groups or show limited substrate scope. Now, use of a pentavalent sulfone-bridged bismacycle, formed in situ by telescoped boron-to-bismuth transmetallation and oxidation, allows the direct and regioselectiveortho-arylation of unprotected phenols.
Adrien Le Roch and Alexandre Gagnon.